Details of the Target
General Information of Target
| Target ID | LDTP18339 | |||||
|---|---|---|---|---|---|---|
| Target Name | Small proline-rich protein 2G (SPRR2G) | |||||
| Gene Name | SPRR2G | |||||
| Gene ID | 6706 | |||||
| Synonyms |
Small proline-rich protein 2G; SPR-2G |
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| 3D Structure | ||||||
| Sequence |
MAAAVRCMGRALIHHQRHSLSKMVYQTSLCSCSVNIRVPNRHFAAATKSAKKTKKGAKEK
TPDEKKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQS VYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEINKVAVFTENASEVKIAEENGAAFAGG TSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNG HEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTS EGLLLKIDPLLPKEVKNEESEKEDA |
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| Target Bioclass |
Other
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| Family |
Cornifin (SPRR) family
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| Subcellular location |
Cytoplasm
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| Function |
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C23(1.68); C27(1.68) | LDD0080 | [1] | |
Competitor(s) Related to This Target