Details of the Target

General Information of Target

Target ID LDTP18327
Target Name Sperm protein associated with the nucleus on the X chromosome D (SPANXD)
Gene Name SPANXD
Gene ID 64648
Synonyms
SPANXE; Sperm protein associated with the nucleus on the X chromosome D; Cancer/testis antigen 11.4; CT11.4; Nuclear-associated protein SPAN-Xd; SPANX-D; SPANX family member D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSQKYCFKENENVTVDKACFLISNITIGPESINLQQEALQRIISTLANKNDEIQNFIDT
LHHTLKGVQENSSNILSELDEEFDSLYSILDEVKESMINCIKQEQARKSQELQSQISQCN
NALENSEELLEFATRSLDIKEPEEFSKAARQIKDRVTMASAFRLSLKPKVSDNMTHLMVD
FSQERQMLQTLKFLPVPKAPEIDPVECLVADNSVTVAWRMPEEDNKIDHFILEHRKTNFD
GLPRVKDERCWEIIDNIKGTEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKAL
NFNLDNSSSHLNLKVEDTCVEWDPTGGKGQESKIKGKENKGRSGTPSPKRTSVGSRPPAV
RGSRDRFTGESYTVLGDTAIESGQHYWEVKAQKDCKSYSVGVAYKTLGKFDQLGKTNTSW
CIHVNNWLQNTFAAKHNNKVKALDVTVPEKIGVFCDFDGGQLSFYDANSKQLLYSFKTKF
TQPVLPGFMVWCGGLSLSTGMQVPSAVRTLQKSENGMTGSASSLNNVVTQ
Target Bioclass
Other
Family
SPAN-X family
Subcellular location
Cytoplasm
Uniprot ID
Q9BXN6
Ensemble ID
ENST00000370515.3
HGNC ID
HGNC:14332

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C16(1.67)  LDD3465  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HT-1197 C16(0.94)  LDD2369  [1]
 LDCM0023  KB03 TCCSUP C16(1.51)  LDD3048  [1]
 LDCM0024  KB05 TCCSUP C16(1.67)  LDD3465  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SET-binding protein (SETBP1) . Q9Y6X0

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060