Details of the Target

General Information of Target

Target ID LDTP18306
Target Name Alpha/beta-tubulin-N-acetyltransferase 9 (NAT9)
Gene Name NAT9
Gene ID 26151
Synonyms
EBS; Alpha/beta-tubulin-N-acetyltransferase 9; EC 2.3.1.308; Embryo brain-specific protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKP
VLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQ
VW
Target Bioclass
Enzyme
Family
Acetyltransferase family, GNAT subfamily
Function N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin.
Uniprot ID
Q9BTE0
Ensemble ID
ENST00000357814.8
HGNC ID
HGNC:23133

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(0.96)  LDD2419  [1]
IA-alkyne
 Probe Info  		C602(0.00); C325(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 KMRC-1 C56(0.96)  LDD2419  [1]
 LDCM0024  KB05 KMRC-1 C56(1.47)  LDD3253  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1) . O43324

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060