Details of the Target

General Information of Target

Target ID LDTP18302
Target Name Tripartite motif-containing protein 51 (TRIM51)
Gene Name TRIM51
Gene ID 84767
Synonyms
SPRYD5; Tripartite motif-containing protein 51; SPRY domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKV
SKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIE
FHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENN
VCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNG
ALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNK
NSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEE
LEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFA
YEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNIL
TDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEG
KPSDAESSESSDDEKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEE
FRSFKDSATKQKLMNKTLEDRLKIEAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAE
KLHRQERKRLRRSAGHLKSRHKRGRSFH
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Uniprot ID
Q9BSJ1
Ensemble ID
ENST00000244891.3
HGNC ID
HGNC:19023

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.E344Ter .
DU145 SNV: p.W168C .
FADU SNV: p.T276I; p.L279M .
GB1 SNV: p.E364D .
HCC15 SNV: p.E375K .
HCT116 SNV: p.V398M .
HSC3 SNV: p.T393A .
KELLY SNV: p.K203M .
MFE319 SNV: p.M144I .
NB4 SNV: p.M95I .
NCIH1793 SNV: p.H121Q .
NUGC3 SNV: p.S263F .
SKMEL30 SNV: p.T337P .
U118MG SNV: p.L41I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C733(0.00); C848(0.00)  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060