Details of the Target

General Information of Target

Target ID LDTP18299
Target Name Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDXACB1)
Gene Name FDXACB1
Gene ID 91893
Synonyms
Ferredoxin-fold anticodon-binding domain-containing protein 1; FDX-ACDB domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGVLPLRGLRALCRVLLFLSQFCILSGGEQSQALAQSIKDPGPTRTFTVVPRAAESTE
IPPYVMKCPSNGLCSRLPADCIDCTTNFSCTYGKPVTFDCAVKPSVTCVDQDFKSQKNFI
INMTCRFCWQLPETDYECTNSTSCMTVSCPRQRYPANCTVRDHVHCLGNRTFPKMLYCNW
TGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGP
ADGSLYI
Target Bioclass
Enzyme
Uniprot ID
Q9BRP7
Ensemble ID
ENST00000260257.9
HGNC ID
HGNC:25110

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.S469P .
HEP3B217 SNV: p.S218P .
KYM1 SNV: p.G202C .
TC71 SNV: p.L403M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C91(2.08)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C91(2.08)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C91(2.15)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C91(2.96)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myoneurin (MYNN) Krueppel C2H2-type zinc-finger protein family Q9NPC7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 18 (ZSCAN18) Krueppel C2H2-type zinc-finger protein family Q8TBC5

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060