Details of the Target

General Information of Target

Target ID LDTP18295
Target Name Osteoclast stimulatory transmembrane protein (OCSTAMP)
Gene Name OCSTAMP
Gene ID 128506
Synonyms
C20orf123; Osteoclast stimulatory transmembrane protein; OC-STAMP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYFRTPQTHPGPLPSGQGGAASPGLSLGLCSPVEPVVVASGGTGPLSQKAEQVAPAAQA
WGPALAMPQARGCPGGTSWETLRKEYSRNCHKFPHVRQLESLGWDNGYSRSRAPDLGGPS
RPRPLMLCGLSPRVLPVPSEAVGKEASSQPDICILTLAMMIAGIPTVPVPGVREEDLIWA
AQAFMMAHPEPEGAVEGARWEQAHAHTASGKMPLVRSKRGQPPGSCL
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation.
Uniprot ID
Q9BR26
Ensemble ID
ENST00000279028.3
HGNC ID
HGNC:16116

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C192(0.00); C25(0.00); C345(0.00)  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060