Details of the Target

General Information of Target

Target ID LDTP18269
Target Name Serine incorporator 2 (SERINC2)
Gene Name SERINC2
Gene ID 347735
Synonyms
TDE2L; Serine incorporator 2; Tumor differentially expressed protein 2-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEILPYSEDKMGRFGADPEGSDLSFSCRLQDTNSFFAGNQAKRPPKLGQIGRAKRVVIE
DDRIDDVLKGMGEKPPSGV
Target Bioclass
Other
Family
TDE1 family
Subcellular location
Membrane
Uniprot ID
Q96SA4
Ensemble ID
ENST00000373709.8
HGNC ID
HGNC:23231

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.T144A .
Ishikawa (Heraklio) 02 ER SNV: p.Y314N .
NCIH1155 SNV: p.A253T .
NCIH661 SNV: p.Q64H IA-alkyne    Probe Info 
RKO SNV: p.G84D .
RVH421 SNV: p.W283L .
SKNSH SNV: p.L91M .
SNGM SNV: p.E194Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C205(1.62)  LDD3410  [1]
IA-alkyne
 Probe Info  		C455(0.00); C385(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A431 C205(2.13)  LDD2258  [1]
 LDCM0023  KB03 A431 C205(3.50)  LDD2675  [1]
 LDCM0024  KB05 RPMI-7951 C205(1.62)  LDD3410  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060