Details of the Target

General Information of Target

Target ID LDTP18236
Target Name Coiled-coil domain-containing protein 85A (CCDC85A)
Gene Name CCDC85A
Gene ID 114800
Synonyms
KIAA1912; Coiled-coil domain-containing protein 85A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAEVHGSPPASLCPCQSVKFRPGLPEMALLTALDDTLPEEAQGPGRRMILLSTPSQSDA
LRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQK
GRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQS
GRAPTQASIRCNAAPIG
Target Bioclass
Other
Family
CCDC85 family
Subcellular location
Cell junction, adherens junction
Function May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.
Uniprot ID
Q96PX6
Ensemble ID
ENST00000407595.3
HGNC ID
HGNC:29400

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C265(1.11); C180(0.85)  LDD3364  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C180(2.14)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C180(2.51)  LDD2660  [1]
 LDCM0024  KB05 NCI-N87 C265(1.11); C180(0.85)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840