General Information of Target

Target ID LDTP18215
Target Name Nucleolar protein 4-like (NOL4L)
Gene Name NOL4L
Gene ID 140688
Synonyms
C20orf112; C20orf113; Nucleolar protein 4-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPSEVAAIAPGEGDGGGGGFGSWLDGRLEALGVDRAVYGAYILGILQEEEEEEKLDAL
QGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPRMV
SEEEKQRKAALLAQYADVTDEEDEADEKDDSGATTMNIGSDKLLFRNTNVEDVLNARKLE
RDSLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQRGERKR
Target Bioclass
Other
Uniprot ID
Q96MY1
Ensemble ID
ENST00000359676.9
HGNC ID
HGNC:16106

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info 
C223(0.00); C148(0.00)  LDD0241  [1]
DBIA
 Probe Info 
C148(1.70)  LDD3314  [2]
IA-alkyne
 Probe Info 
N.A.  LDD2241  [3]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [3]
TFBX
 Probe Info 
N.A.  LDD0148  [4]
W1
 Probe Info 
C148(0.00); C111(0.00)  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C223(1.37); C148(1.51)  LDD2247  [2]
 LDCM0023  KB03 786-O C223(1.64); C148(1.56)  LDD2664  [2]
 LDCM0024  KB05 IGR37 C148(1.70)  LDD3314  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255