General Information of Target

Target ID LDTP18204
Target Name bMERB domain-containing protein 1 (BMERB1)
Gene Name BMERB1
Gene ID 89927
Synonyms
C16orf45; bMERB domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQ
KKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQ
HMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVS
MRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWES
RWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRS
DIWAEVKKKEQQRVRI
Target Bioclass
Other
Uniprot ID
Q96MC5
Ensemble ID
ENST00000300006.9
HGNC ID
HGNC:19213

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.V124GfsTer27 .
HCT15 SNV: p.E141K .
KYM1 SNV: p.L159V DBIA    Probe Info 
YSCCC SNV: p.Q111H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C84(2.45)  LDD3401  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C84(1.82)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C84(1.64)  LDD2661  [1]
 LDCM0024  KB05 RD C84(2.45)  LDD3401  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840