Details of the Target

General Information of Target

Target ID LDTP18203
Target Name Coiled-coil domain-containing protein 42 (CCDC42)
Gene Name CCDC42
Gene ID 146849
Synonyms
CCDC42A; Coiled-coil domain-containing protein 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNNHWFQSSQVPSFAQMLKKNLPVQPATKTITTPTGWSSESYGLSKMASKVTQVTGNF
PEPLLSKNLSSISNPVLPPKKIPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETVTT
GNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPP
FPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFIIE
RAGQHEVVAIGTGEYNYSQDIKPDGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMM
EKSIFCTEPTSNLLTLKQNINICLYMNQLPKGSAQIKSQLRLNPHSISAFEANEELCLHV
AVEGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILIGDGN
CSDTRGLEIAIKQRVDDALTSKLPMFYLVNRPHISLVPSAYPLQMNLEYKFLSLNWAQGD
VSLEIVDGLSGKITESSPFKSGMSMASRLCKAAMLSRFNLLAKEAKKELLEAGTYHAAKC
MSASYQEAKCKLKSYLQQHGYGSWIVKSPCIEQFNM
Target Bioclass
Other
Family
CFAP73 family
Function Required for sperm development.
Uniprot ID
Q96M95
Ensemble ID
ENST00000293845.8
HGNC ID
HGNC:26528

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.L30V .
HCC827 SNV: p.D211N .
LU65 SNV: p.K210N .
SNGM Insertion: p.R128AfsTer43 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C119(20.00)  LDD2227  [1]
Acrolein
 Probe Info  		N.A.  LDD0231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C119(20.00)  LDD2227  [1]
 LDCM0109  NEM HeLa N.A.  LDD0231  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.