General Information of Target

Target ID LDTP18178
Target Name Zinc finger and BTB domain-containing protein 45 (ZBTB45)
Gene Name ZBTB45
Gene ID 84878
Synonyms
ZNF499; Zinc finger and BTB domain-containing protein 45; Zinc finger protein 499
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVT
VSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKY
FASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLAT
VTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVL
VDLSAFLVSSDLTYVYQWPWTLLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRI
MVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARKHLLPVTTADLSSKER
HRSPLEKPHNGLLFPQHGDYQYGRNNILTDHFQYSRQSYPNSYSLNRYDV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation.
Uniprot ID
Q96K62
Ensemble ID
ENST00000354590.7
HGNC ID
HGNC:23715

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C49(2.47)  LDD2469  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MGG123 C49(2.47)  LDD2469  [1]
 LDCM0023  KB03 MGG123 C49(3.35)  LDD2886  [1]
 LDCM0024  KB05 MGG123 C49(2.82)  LDD3303  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840