Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP18171
Target Name	RNA exonuclease 5 (REXO5)
Gene Name	REXO5
Gene ID	81691
Synonyms	RNA exonuclease 5; EC 3.1.-.-; Exonuclease NEF-sp
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAAAPPPP SSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVE LADPAGSDGRLAPGSAGSGSGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFF IHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKR YAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHC LSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTV PVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEP EPSPKALPEPLPAPPEDKK
Target Bioclass	Enzyme
Uniprot ID	Q96IC2
Ensemble ID	ENST00000261377.11
HGNC ID	HGNC:24661

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
AN3CA	SNV: p.R519G			.
HCT116	SNV: p.A21S			.
HEL	Insertion: p.L436FfsTer9			.
HEL9217	Insertion: p.L436FfsTer9			.
HUH7	SNV: p.S78C			.
IGROV1	Deletion: p.K386RfsTer5			.
KYM1	SNV: p.E503Q			.
SG231	SNV: p.L707F			.
SKMEL24	SNV: p.P530S			.
SKNSH	SNV: p.Q20K			.
TF1	Deletion: p.P22QfsTer11			.
WM115	SNV: p.S481F			.
WM2664	SNV: p.S481F			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Acrolein Probe Info			N.A.	LDD0222	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[1]

References

1	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.