Details of the Target

General Information of Target

Target ID LDTP18170
Target Name Protein ABHD8 (ABHD8)
Gene Name ABHD8
Gene ID 79575
Synonyms
Protein ABHD8; EC 3.-.-.-; Alpha/beta hydrolase domain-containing protein 8; Abhydrolase domain-containing protein 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPLLGLLLVFAGCTFALYLLSTRLPRGRRLGSTEEAGGRSLWFPSDLAELRELSEVLRE
YRKEHQAYVFLLFCGAYLYKQGFAIPGSSFLNVLAGALFGPWLGLLLCCVLTSVGATCCY
LLSSIFGKQLVVSYFPDKVALLQRKVEENRNSLFFFLLFLRLFPMTPNWFLNLSAPILNI
PIVQFFFSVLIGLIPYNFICVQTGSILSTLTSLDALFSWDTVFKLLAIAMVALIPGTLIK
KFSQKHLQLNETSTANHIHSRKDT
Target Bioclass
Enzyme
Family
AB hydrolase superfamily
Uniprot ID
Q96I13
Ensemble ID
ENST00000247706.4
HGNC ID
HGNC:23759

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C206(0.00); C255(0.00)  LDD0161  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853