Details of the Target
General Information of Target
| Target ID | LDTP18160 | |||||
|---|---|---|---|---|---|---|
| Target Name | Calmodulin-like protein 4 (CALML4) | |||||
| Gene Name | CALML4 | |||||
| Gene ID | 91860 | |||||
| Synonyms |
Calmodulin-like protein 4; Serologically defined breast cancer antigen NY-BR-20 |
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| 3D Structure | ||||||
| Sequence |
MASVALEDVAVNFTREEWALLGPCQKNLYKDVMQETIRNLDCVGMKWKDQNIEDQYRYPR
KNLRCRMLERFVESKDGTQCGETSSQIQDSIVTKNTLPGVGPYESRMSGEVIMGHSSLNC YIRVGAGHKPYEYHECGEKPDTHKQRGKAFSYHNSLQTHERLHTGKKPYNCKECGKSFSS LGNLQRHMAVQRGDGPYKCKLCGKAFFWPSLLHMHERTHTGEKPYECKQCSKAFSFYSSY LRHERTHTGEKLYECKQCSKAFPDYSSCLRHERTHTGKKPYTCKQCGKAFSASTSLRRHE TTHTDEKPYACQQCGKAFHHLGSFQRHMVMHTRDGPHKCKICGKGFDCPSSLKSHERTHT GEKLYECKQCGKALSHSSSFRRHMTMHTGDGPHKCKICGKAFVYPSVFQRHEKTHTAEKP YKCKQCGKAYRISSSLRRHETTHTGEKPYKCKCGKAFIDFYSFQNHKTTHAGEKPYECKE CGKAFSCFQYLSQHRRTHTGEKPYECNTCKKAFSHFGNLKVHERIHSGEKPYECKECGKA FSWLTCFLRHERIHMREKPYECQQCGKAFTHSRFLQGHEKTHTGENPYECKECGKAFASL SSLHRHKKTHWKKTHTGENPYGCKECGKAFASLSSLHRHKKTH |
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| Target Bioclass |
Other
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| Family |
Calmodulin family
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| Function |
As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C82(1.71) | LDD3364 | [1] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0161 | [2] | |
Competitor(s) Related to This Target
References