Details of the Target

General Information of Target

Target ID LDTP18150
Target Name PHD finger protein 21B (PHF21B)
Gene Name PHF21B
Gene ID 112885
Synonyms
KIAA1661; PHD finger protein 21B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKLYSENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGKTGDEEMLK
DKGKPESEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPGSETRAAGKRPAED
DVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQDEKRKSKQKLGAFL
WMQRNLQDPFYPRGPREFRGGCRAPRRDIEDIPYV
Target Bioclass
Other
Uniprot ID
Q96EK2
Ensemble ID
ENST00000313237.10
HGNC ID
HGNC:25161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 SNV: p.N310T .
NCIH1793 Deletion: p.P86RfsTer58 .
NCIH2286 SNV: p.P271T .
NCIH2291 SNV: p.L181F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		N.A.  LDD0246  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060