Details of the Target
General Information of Target
| Target ID | LDTP18141 | |||||
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| Target Name | Leucine-rich repeat-containing protein 39 (LRRC39) | |||||
| Gene Name | LRRC39 | |||||
| Gene ID | 127495 | |||||
| Synonyms |
Leucine-rich repeat-containing protein 39; Myosin-interacting M-band-associated stress-responsive protein; Myomasp |
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| 3D Structure | ||||||
| Sequence |
MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA
ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSN QALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES EAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQH MLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTE DAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEG LWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLW PGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQ DRVYALQQTALQG |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm, myofibril, sarcomere, M line
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| Function |
Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IA-alkyne Probe Info |
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N.A. | LDD0161 | [1] | |
The Interaction Atlas With This Target