Details of the Target

General Information of Target

Target ID LDTP18139
Target Name Kelch-like protein 29 (KLHL29)
Gene Name KLHL29
Gene ID 114818
Synonyms
KBTBD9; KIAA1921; Kelch-like protein 29; Kelch repeat and BTB domain-containing protein 9
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPPSAPLPAQGPGKARPSRKRGRRPRALKFVDVAVYFSPEEWGCLRPAQRALYRDVMRE
TYGHLGALGCAGPKPALISWLERNTDDWEPAALDPQEYPRGLTVQRKSRTRKKNGEKEVF
PPKEAPRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPDHQALESHKCAQNLKKPYPCP
DCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGR
CFRRSRSLANHRTTHTGEKPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECNRRFRQ
RTALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTL
LQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHR
RVHSGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCFRQRWSLAVHKCSPK
APNCSPRSAIGGSSQRGNAH
Target Bioclass
Other
Uniprot ID
Q96CT2
Ensemble ID
ENST00000486442.6
HGNC ID
HGNC:29404

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Deletion: p.S188HfsTer12 .
COLO679 SNV: p.G154E .
EFO21 SNV: p.N282T .
HCT116 SNV: p.P190H; p.A714G .
HCT15 SNV: p.G337S .
HSC3 SNV: p.T286A .
KYM1 SNV: p.P60L .
MCC13 Substitution: p.R668N .
MEWO Substitution: p.P312R .
OPM2 SNV: p.P264S .
PC9 Deletion: p.Q363TfsTer68 .
SKNSH SNV: p.P284H .
WM115 SNV: p.G165E .
WM2664 SNV: p.G165E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C728(3.69)  LDD3383  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C420(1.92)  LDD2250  [1]
 LDCM0023  KB03 A101D C420(3.88)  LDD2667  [1]
 LDCM0024  KB05 OVCAR-5 C728(3.69)  LDD3383  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NudC domain-containing protein 3 (NUDCD3) . Q8IVD9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060