Details of the Target

General Information of Target

Target ID LDTP18124
Target Name Protein FAM131C (FAM131C)
Gene Name FAM131C
Gene ID 348487
Synonyms
C1orf117; Protein FAM131C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAARPSLGRVLPGSSVLFLCDMQEKFRHNIAYFPQIVSVAARMLKVARLLEVPVMLTEQ
YPQGLGPTVPELGTEGLRPLAKTCFSMVPALQQELDSRPQLRSVLLCGIEAQACILNTTL
DLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSEGLILQLVGDAVHPQFKEI
QKLIKEPAPDSGLLGLFQGQNSLLH
Target Bioclass
Other
Family
FAM131 family
Uniprot ID
Q96AQ9
Ensemble ID
ENST00000375662.5
HGNC ID
HGNC:26717

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C4(4.07)  LDD1702  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4(4.07)  LDD1702  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Hippocalcin-like protein 4 (HPCAL4) Recoverin family Q9UM19
Visinin-like protein 1 (VSNL1) Recoverin family P62760
LIM domain only protein 3 (LMO3) . Q8TAP4

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060