Details of the Target
General Information of Target
| Target ID | LDTP18105 | |||||
|---|---|---|---|---|---|---|
| Target Name | Voltage-dependent calcium channel gamma-like subunit (TMEM37) | |||||
| Gene Name | TMEM37 | |||||
| Gene ID | 140738 | |||||
| Synonyms |
PR; Voltage-dependent calcium channel gamma-like subunit; Neuronal voltage-gated calcium channel gamma-like subunit; Transmembrane protein 37 |
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| 3D Structure | ||||||
| Sequence |
MSKSTKLCGKTSCPRSNIFCNLLDKIVKRPSLQFLGQWGYHCYEPRIYRSLAKILRYVDL
DGFDALLTDYIAFVEKSGYRFEVSFNLDFTEICVNTILYWVFARKGNPDFVELLLKKTKD YVQDRSCNLALIWRTFTPVYCPSPLSGITPLFYVAQTRQSNIFKILLQYGILEREKNPIN IVLTIVLYPSRVRVMVDRELADIHEDAKTCLVLCSRVLSVISVKEIKTQLSLGRHPIISN WFDYIPSTRYKDPCELLHLCRLTIRNQLLTNNMLPDGIFSLLIPARLQNYLNLEI |
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| Target Bioclass |
Transporter and channel
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| Family |
PMP-22/EMP/MP20 family, CACNG subfamily
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| Subcellular location |
Membrane
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| Function | Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
YN-1 Probe Info |
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100.00 | LDD0444 | [1] | |