Details of the Target

General Information of Target

Target ID LDTP18090
Target Name Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)
Gene Name PPP1R1C
Gene ID 151242
Synonyms
Protein phosphatase 1 regulatory subunit 1C; Inhibitor-5 of protein phosphatase 1; IPP5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKR
RGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWR
QWHYDGLHPSYLYNRHHT
Target Bioclass
Enzyme
Family
Protein phosphatase inhibitor 1 family
Subcellular location
Cytoplasm
Function May increase cell susceptibility to TNF-induced apoptosis.
Uniprot ID
Q8WVI7
Ensemble ID
ENST00000280295.7
HGNC ID
HGNC:14940

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K8Q .
CAOV3 SNV: p.Q68H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transportin-3 (TNPO3) . Q9Y5L0

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060