Details of the Target

General Information of Target

Target ID LDTP18082
Target Name Solute carrier family 25 member 43 (SLC25A43)
Gene Name SLC25A43
Gene ID 203427
Synonyms
Solute carrier family 25 member 43
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPKRSQKESVLITGGSGYFGFRLGCALNQNGVHVILFDISSPAQTIPEGIKFIQGDIRH
LSDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVY
TSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEQKVLEANATPLDRGDGVLRT
CALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHILASEALR
ADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLVYCFAFLTEMVHFI
LGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYKAQPFDLQEAVEWFKAHGHGRSSG
SRDSECFVWDGLLVFLLIIAVLMWLPSSVILSL
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Uniprot ID
Q8WUT9
Ensemble ID
ENST00000217909.8
HGNC ID
HGNC:30557

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 SNV: p.N72S; p.P176S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.