General Information of Target

Target ID LDTP18078
Target Name Scavenger receptor cysteine-rich domain-containing group B protein (SSC4D)
Gene Name SSC4D
Gene ID 136853
Synonyms
SRCRB4D; Scavenger receptor cysteine-rich domain-containing group B protein; Four scavenger receptor cysteine-rich domains-containing protein; S4D-SRCRB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVTFALLLLLGQATADPCYDPQGRPQFCLPPVTQLAAVAASCPQACALSPGNHLGARET
CNGSLTLALGGPFLLTSVSLRFCTPGPPALILSAAWASGGPWRLLWHRPAWPGALGGPER
VTFHSTPGPKATVAASHLRVEFGGQAGLAAAGLRGRCQCHGHAARCAARARPPRCHCRHH
TTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCE
RCRHHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGV
TGLTCNRCGPGYQQSRSPRMPCQRIPEATTTLATTPGAYSSDPQCQNYCNMSDTRVHMSL
RRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQRAQPVRRGDQDAWVPRADLTCGC
LRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRLQQEERAGGCRGVRA
PTPSPRPEH
Target Bioclass
Enzyme
Subcellular location
Secreted
Uniprot ID
Q8WTU2
Ensemble ID
ENST00000275560.4
HGNC ID
HGNC:14461

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P389S .
COLO792 SNV: p.E545K .
HSC3 SNV: p.P352S .
HT3 SNV: p.E384K .
IM95 SNV: p.H480R .
Ishikawa (Heraklio) 02 ER SNV: p.C382R .
LNCaP clone FGC SNV: p.E437Ter .
MOLT4 SNV: p.D91Y .
TF1 SNV: p.G355C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info 
C353(0.00); C198(0.00)  LDD0241  [1]
IA-alkyne
 Probe Info 
C776(0.00); C18(0.00)  LDD0161  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060