Details of the Target

General Information of Target

Target ID LDTP18070
Target Name Ankyrin repeat domain-containing protein 24 (ANKRD24)
Gene Name ANKRD24
Gene ID 170961
Synonyms
KIAA1981; Ankyrin repeat domain-containing protein 24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSHFTQDFLPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSMNVCKVQKGVYNGINKC
LSNTQSKIFQCNARVKVFSKFANSNKDKTRHTGEKHFKCNECGKSFQKFSDLTQHKGIHA
GEKPYTCEERGKDFGWYTDLNQHKKIHTGEKPYKCEECGKAFNRSTNLTAHKRIHNREKA
YTGEDRDRAFGWSTNLNEYKKIHTGDKPYKCKECGKAFMHSSHLNKHEKIHTGEKPYKCK
ECGKVISSSSSFAKHKRIHTGEKPFKCLECGKAFNISTTLTKHRRIHTGEKPYTCEVCGK
AFRQSANLYVHRRIHTGEKPYTCGECGKTFRQSANLYVHRRIHTGEKPYKCEDCGKAFGR
YTALNQHKKIHTGEKPYKCEECGKAFNSSTNLTAHKRIHTREKPYTCEDRGRAFGLSTNL
NEYKKIHTGDKPYKCKECGKAFIHSLHLNKHEKIHTGKKPYKCKQCGKVITSSSSFAKHK
RIHTGEKPFECLECGKAFTSSTTLTKHRRIHTGEKPYTCEVCGKAFRQSAILYVHRRIHT
GEKPYTCEECGKTFRQSANLYVHRRIHTGEKPYKCEECGKAFGRYTDLNQHKKIHTGEKL
YKCEECGKDFVWYTDLNQQKKIYTGEKPYKCEECGKAFAPSTDLNQHTKILTGEQSYKCE
ECGKAFGWSIALNQHKKIHTGEKPYKCEECGKAFSRSRNLTTHRRVHTREKPYKCEDRGR
SFGWSTNLNEYKKIHTGDKLYKCKECGKVFKQSSHLNRHEKIHTGKKPYKCKECGKVITS
SSSFAKHKRIHTGEKPFKCLECGKAFTSSTTLTKHRRIHTGEKPYTCEECGKAFRQSAIL
YVHRRIHTGEKPYTCGECGKTFRQSANLYAHKKIHTGEKPYTCGDCGKTFRQSANLYAHK
KIHTGDKTIQV
Target Bioclass
Other
Function
Componement of the stereocilia rootlet in hair cells of inner ear. Bridges the apical plasma membrane with the lower rootlet and maintains normal distribution of TRIOBP, thereby reinforcing stereocilia insertion points and organizing rootlets for hearing with long-term resilience.
Uniprot ID
Q8TF21
Ensemble ID
ENST00000262970.9
HGNC ID
HGNC:29424

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.C222Y .
CAOV3 SNV: p.T1022I .
COLO792 SNV: p.E605K .
DU145 SNV: p.A504V .
HCT15 SNV: p.E522Ter .
IGR1 SNV: p.G533E .
IPC298 SNV: p.K720E .
Ishikawa (Heraklio) 02 ER SNV: p.Q911R .
KELLY SNV: p.D1093G .
KYSE150 SNV: p.E1033A .
L428 SNV: p.E570A .
LNCaP clone FGC SNV: p.K47E .
MCC13 SNV: p.P695L .
MEC1 SNV: p.E865Ter; p.R1038H .
MFE319 SNV: p.Q248Ter .
MOLM16 SNV: p.E893D .
NCIH1155 SNV: p.E401K .
NCIH146 SNV: p.D282Y .
NCIH1944 SNV: p.A61S .
NCIH2170 SNV: p.R896Q .
OVK18 SNV: p.Q338Ter; p.A1086T .
RL952 SNV: p.R896Q .
SKNAS SNV: p.L798H .
TCCSUP SNV: p.Q980P .
YSCCC SNV: p.E50K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C168(1.04)  LDD2123  [1]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C168(1.04)  LDD2123  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C168(1.31)  LDD2137  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C168(1.13)  LDD2140  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.