General Information of Target

Target ID LDTP18069
Target Name Zinc finger protein 721 (ZNF721)
Gene Name ZNF721
Gene ID 170960
Synonyms
KIAA1982; Zinc finger protein 721
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQ
IGIEWNLSPVGRVTPKEWKHQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8TF20
Ensemble ID
ENST00000338977.5
HGNC ID
HGNC:29425

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C42(2.27)  LDD3376  [1]
IPM
 Probe Info 
N.A.  LDD2156  [2]
HHS-465
 Probe Info 
K151(0.00); K154(0.00); Y153(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C42(1.66)  LDD2254  [1]
 LDCM0023  KB03 A2780 C42(1.98)  LDD2671  [1]
 LDCM0024  KB05 ONS-76 C42(2.27)  LDD3376  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010