Details of the Target
General Information of Target
| Target ID | LDTP18058 | |||||
|---|---|---|---|---|---|---|
| Target Name | Interferon-induced protein 44 (IFI44) | |||||
| Gene Name | IFI44 | |||||
| Gene ID | 10561 | |||||
| Synonyms |
MTAP44; Interferon-induced protein 44; p44; Microtubule-associated protein 44 |
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| 3D Structure | ||||||
| Sequence |
MTQTLDTREDPLNLGGGGGGGCGCGWAHSASLSSWSSCHRRRPGAPAYNRPHRYSPKTEY
GPPRKQPKQQHGPGFWFQPPVCSNWGCWGGPWRPPPPGFWKFPCPVQVFRVYGLHPLCFC CCSCWSGSWNPGWVKPPGRKKRWGRRGRGLRHHPRHSYPRSPPADVSTLPRPVKLYEWRE PGMRAPPNTTQFIMNQIYEDMRQQEKVERQQEALRAQKATVSGEASPARSSGNDAPPGGS KETWGLQETLYGFVQNPSLAFSPNPEENQSLAPLLVEEEEEKKNDDEEEYDQEVCDAKEA SEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEELEEEEEVLEENEQRGEEFHLP LEMPLSIFVEAEEKRENFISCTFLNPEQIIPKVPQESLFMAQDFNC |
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| Target Bioclass |
Other
|
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| Family |
IFI44 family
|
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| Subcellular location |
Cytoplasm
|
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| Function | This protein aggregates to form microtubular structures. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAOV3 | SNV: p.A417V | DBIA Probe Info | |||
| HCC44 | SNV: p.E157K | DBIA Probe Info | |||
| ICC12 | SNV: p.C151W | DBIA Probe Info | |||
| MFE319 | Insertion: p.Ter445IfsTer4 | . | |||
| NCIH2291 | SNV: p.E229K | . | |||
| SUDHL6 | SNV: p.Y146D | DBIA Probe Info | |||
| WM2664 | Insertion: p.D403GfsTer17 | . | |||
| WM793 | SNV: p.Q322Ter | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C250(2.73) | LDD3311 | [1] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0161 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References