Details of the Target

General Information of Target

Target ID LDTP18050
Target Name Spermatogenesis-associated protein 20 (SPATA20)
Gene Name SPATA20
Gene ID 64847
Synonyms
Spermatogenesis-associated protein 20; Sperm-specific protein 411; Ssp411
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSPVSRDASDALQGRKCLRPRSRRLPLPAAVRAHGPMAELTDSARGCVVFEDVFVYFSR
EEWELLDDAQRLLYHDVMLENFALLASLGIAFSRSRAVMKLERGEEPWVYDQVDMTSATE
REAQRGLRPGCWHGVEDEEVSSEQSIFVAGVSEVRTLMAELESHPCDICGPILKDTLHLA
KYHGGKARQKPYLCGACGKQFWFSTDFDQHQNQPNGGKLFPRKEGRDSVKSCRVHVPEKT
LTCGKGRRDFSATSGLLQHQASLSSMKPHKSTKLVSGFLMGQRYHRCGECGKAFTRKDTL
ARHQRIHTGERPYECNECGKFFSQSYDLFKHQTVHTGERPYECSECGKFFRQISGLIEHR
RVHTGERLYQCGKCGKFFSSKSNLIRHQEVHTGARPYVCSECGKEFSRKHTLVLHQRTHT
GERPYECSECGKAFSQSSHLNVHWRIHSSDYECSRCGKAFSCISKLIQHQKVHSGEKPYE
CSKCGKAFTQRPNLIRHWKVHTGERPYVCSECGREFIRKQTLVLHQRVHAGEKL
Target Bioclass
Other
Subcellular location
Secreted
Function May play a role in fertility regulation.
Uniprot ID
Q8TB22
Ensemble ID
ENST00000006658.11
HGNC ID
HGNC:26125

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K497(7.67)  LDD0277  [1]
DBIA
 Probe Info  		C637(0.96)  LDD3332  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C671(0.85)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C671(0.94)  LDD1574  [5]
 LDCM0374  CL105 HEK-293T C671(0.93)  LDD1578  [5]
 LDCM0378  CL109 HEK-293T C671(0.85)  LDD1582  [5]
 LDCM0383  CL113 HEK-293T C671(0.92)  LDD1587  [5]
 LDCM0387  CL117 HEK-293T C671(0.96)  LDD1591  [5]
 LDCM0392  CL121 HEK-293T C671(0.94)  LDD1596  [5]
 LDCM0396  CL125 HEK-293T C671(0.90)  LDD1600  [5]
 LDCM0400  CL13 HEK-293T C671(0.90)  LDD1604  [5]
 LDCM0413  CL25 HEK-293T C671(1.06)  LDD1617  [5]
 LDCM0426  CL37 HEK-293T C671(1.08)  LDD1630  [5]
 LDCM0439  CL49 HEK-293T C671(1.02)  LDD1643  [5]
 LDCM0453  CL61 HEK-293T C671(0.95)  LDD1656  [5]
 LDCM0466  CL73 HEK-293T C671(0.97)  LDD1669  [5]
 LDCM0479  CL85 HEK-293T C671(0.94)  LDD1682  [5]
 LDCM0492  CL97 HEK-293T C671(0.95)  LDD1695  [5]
 LDCM0022  KB02 A101D C737(1.70)  LDD2250  [2]
 LDCM0023  KB03 A101D C737(2.66)  LDD2667  [2]
 LDCM0024  KB05 MKN45 C637(0.96)  LDD3332  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402