Details of the Target
General Information of Target
| Target ID | LDTP17804 | |||||
|---|---|---|---|---|---|---|
| Target Name | E3 ubiquitin-protein ligase ZSWIM2 (ZSWIM2) | |||||
| Gene Name | ZSWIM2 | |||||
| Gene ID | 151112 | |||||
| Synonyms |
ZZZ2; E3 ubiquitin-protein ligase ZSWIM2; EC 2.3.2.27; MEKK1-related protein X; MEX; RING-type E3 ubiquitin transferase ZSWIM2; ZZ-type zinc finger-containing protein 2; Zinc finger SWIM domain-containing protein 2
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| 3D Structure | ||||||
| Sequence |
MAESQLNCLDEAHVNEKVTEAQAAFYYCERRRAALEALLGGGEQAYRERLKEEQLRDFLS
SPERQALRAAWSPYEDAVPAANARGKSKAKAKAPAPAPAESGESLAYWPDRSDTEVPPLD LGWTDTGFYRGVSRVTLFTHPPKDEKAPHLKQVVRQMIQQAQKVIAVVMDLFTDGDIFQD IVDAACKRRVPVYIILDEAGVKYFLEMCQDLQLTDFRIRNIRVRSVTGVGFYMPMGRIKG TLSSRFLMVDGDKVATGSYRFTWSSSHVDRNLLLLLTGQNVEPFDTEFRELYAISEEVDL YRQLSLAGRVGLHYSSTVARKLINPKYALVSGCRHPPGEMMRWAARQQREAGGNPEGQEE GASGGESAWRLESFLKDLVTVEQVLPPVEPIPLGELSQKDGRMVSHMHRDLKPKSREAPS RNGMGEAARGEAAPARRFSSRLFSRRAKRPAAPNGMASSVSTETSEVEFLTGKRPNENSS ADISGKTSPSSAKPSNCVIS |
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| Target Bioclass |
Enzyme
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| Function | E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C605(2.41) | LDD2230 | [1] | |
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DBIA Probe Info |
 |
C362(0.92) | LDD3348 | [2] | |
Competitor(s) Related to This Target
References