Details of the Target

General Information of Target

Target ID LDTP17798
Target Name Putative methyltransferase NSUN7 (NSUN7)
Gene Name NSUN7
Gene ID 79730
Synonyms
Putative methyltransferase NSUN7; EC 2.1.1.-; NOL1/NOP2/Sun domain family member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGEITETGELYSSYVGLVYMFNLIVGTGALTMPKAFATAGWLVSLVLLVFLGFMSFVTT
TFVIEAMAAANAQLHWKRMENLKEEEDDDSSTASDSDVLIRDNYERAEKRPILSVQRRGS
PNPFEITDRVEMGQMASMFFNKVGVNLFYFCIIVYLYGDLAIYAAAVPFSLMQVTCSATG
NDSCGVEADTKYNDTDRCWGPLRRVDAYRIYLAIFTLLLGPFTFFDVQKTKYLQILTSLM
RWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSK
RHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLF
PVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLES
LVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRHTFWVGFVLLWAFS
CFIFVTANIILSETKL
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
Function May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
Uniprot ID
Q8NE18
Ensemble ID
ENST00000316607.5
HGNC ID
HGNC:25857

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.Q55K .
MDST8 SNV: p.L398F .
SKMEL2 SNV: p.N621K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C175(0.26)  LDD2149  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C175(0.26)  LDD2149  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761