Details of the Target

General Information of Target

Target ID LDTP17788
Target Name Coiled-coil domain-containing protein 150 (CCDC150)
Gene Name CCDC150
Gene ID 284992
Synonyms
Coiled-coil domain-containing protein 150
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTTKKTLMFLSSFFTSLGSFIVICSILGTQAWITSTIAVRDSASNGSIFITYGLFRGES
SEELSHGLAEPKKKFAVLEILNNSSQKTLHSVTILFLVLSLITSLLSSGFTFYNSISNPY
QTFLGPTGVYTWNGLGASFVFVTMILFVANTQSNQLSEELFQMLYPATTSKGTTHSYGYS
FWLILLVILLNIVTVTIIIFYQKARYQRKQEQRKPMEYAPRDGILF
Target Bioclass
Other
Uniprot ID
Q8NCX0
Ensemble ID
ENST00000389175.9
HGNC ID
HGNC:26834

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HL60 SNV: p.Q411H .
KYM1 Substitution: p.K936_N937delinsNY .
LS180 SNV: p.Q1061L .
MCC26 SNV: p.S817F .
NUGC3 SNV: p.A608V .
OPM2 Deletion: p.E957RfsTer23 .
RT112 SNV: p.K609N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0447  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Nuclear transport factor 2 (NUTF2) . P61970

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.