Details of the Target

General Information of Target

Target ID LDTP17783
Target Name Beta-galactosidase-1-like protein 3 (GLB1L3)
Gene Name GLB1L3
Gene ID 112937
Synonyms
Beta-galactosidase-1-like protein 3; EC 3.2.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESFMESLNRLKEIHEKEVLGLQNKLLELNSERCRDAQRIEELFSKNHQLREQQKTLKEN
LRVLENRLRAGLCDRCMVTQELARKRQQEFESSHLQNLQRIFILTNEMNGLKEENETLKE
EVKRLRGLGDRPKPRAKEGTSDPPSPLLLPSPGGWKAITEKPPGGHEEAEEDHQGVGLRG
EEKPAGHRTSPVAKISPGATLPESRAPDMSPQRISNQLHGTIAVVRPGSQACPADRGPAN
GTPPPLPARSSPPSPAYERGLSLDSFLRASRPSAMTHEAPKLSPKVDRLCLLNRPLSLHL
QSPHSSPLAPAAAPSDPRLQDLKAREAEAWEEPTELLGLPSALAGMQDLRLEGALHLLLA
QQQLRARARAGSVRPRGQPTPGEMLPSLPVGSDSEGPENEGTRAALAAAGLSGGRHTQPA
GPGRAQRTEAAATQDCALDKPLDLSEWGRARGQDTPKPAGQHGSLSPAAAHTASPEPPTQ
SGPLTRSPQALSNGTKGTRVPEQEEASTPMDPSRPLPGSQLSLSSPGSTEDEDTGRPLPP
PHPQPPPHPQPPDLDGHPEPSKAEVLRPESDELDETDTPGSEVGLSSQAEATTSTTGEGP
ECICTQEHGQGPPRKRKRASEPGDKASKKPSRGRRKLTATEGPGSPRDAEDHSPSPNSSP
WEET
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 35 family
Uniprot ID
Q8NCI6
Ensemble ID
ENST00000389887.9
HGNC ID
HGNC:25147

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.L418I .
LS513 SNV: p.G91R .
MCC13 SNV: p.S425F .
MOLT4 SNV: p.P398S .
NCIH2172 SNV: p.F636C .
NCIH358 SNV: p.R214H; p.D234Y .
NUGC3 SNV: p.R101M; p.G453R .
SKNAS SNV: p.R506K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C462(2.31)  LDD3328  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 WM266-4 C462(2.13)  LDD2494  [1]
 LDCM0023  KB03 WM266-4 C462(2.38)  LDD2911  [1]
 LDCM0024  KB05 WM266-4 C462(2.31)  LDD3328  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840