Details of the Target

General Information of Target

Target ID LDTP17782
Target Name RBBP8 N-terminal-like protein (RBBP8NL)
Gene Name RBBP8NL
Gene ID 140893
Synonyms
C20orf151; RBBP8 N-terminal-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLM
PLSHLPLRDSPPLGRRLLPGGPGRADPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYF
LGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGF
LGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASISYDLNRLP
KLIYSLPADVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAQLKSGRDSTV
Target Bioclass
Other
Uniprot ID
Q8NC74
Ensemble ID
ENST00000252998.2
HGNC ID
HGNC:16144

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C76(1.16)  LDD3323  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC12 C76(1.20)  LDD2383  [1]
 LDCM0023  KB03 ICC12 C76(1.17)  LDD2800  [1]
 LDCM0024  KB05 SKMEL24 C76(1.16)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264