Details of the Target

General Information of Target

Target ID LDTP17766
Target Name Tandem C2 domains nuclear protein (TC2N)
Gene Name TC2N
Gene ID 123036
Synonyms
C14orf47; MTAC2D1; Tandem C2 domains nuclear protein; Membrane targeting tandem C2 domain-containing protein 1; Tandem C2 protein in nucleus; Tac2-N
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDP
QQERDFYKTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYER
KVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESFRAFVEDSEDEDGAGEG
GSSLLQKRAKTRQEKAQEEADYIEWLKGQKEIRNPDSLKELTHLKEYWNDPELDEGERFL
RDYILNKRYEEEEEEEEDEEEMEEEEGVHGPPVQLAVDDSSDEGELFLKKQEDFEQKYNF
RFEEPDSASVKTYPRSIASSVRRKDERRKEKREETRERKKREKAKKQEELKQLKNLKRKE
ILAKLEKLRKVTGNEMLGLEEGDLEDDFDPAQHDQLMQKCFGDEYYGAVEEEKPQFEEEE
GLEDDWNWDTWDGPEQEGDWSQQELHCEDPNFNMDADYDPSQPRKKKREAPLTGKKKRKS
PFAAAVGQEKPVFEPGDKTFEEYLDEYYRLDYEDIIDDLPCRFKYRTVVPCDFGLSTEEI
LAADDKELNRWCSLKKTCMYRSEQEELRDKRAYSQKAQNSWKKRQVFKSLCREEAETPAE
ATGKPQRDEAGPQRQLPALDGSLMGPESPPAQEEEAPVSPHKKPAPQKRRRAKKARLLGP
TVMLGGCEFSRQRLQAFGLNPKRLHFRQLGRQRRKQQGPKNSS
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q8N9U0
Ensemble ID
ENST00000340892.9
HGNC ID
HGNC:19859

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.E335K .
HCC1395 SNV: p.K471N .
HCC1954 SNV: p.N38S DBIA    Probe Info 
MCC26 SNV: p.P146S .
MEWO SNV: p.L357S .
NCIH1299 SNV: p.L355R .
TCCSUP SNV: p.F396L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C324(3.81)  LDD3354  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C57(0.88)  LDD2227  [3]
 LDCM0022  KB02 AU565 C158(3.16); C324(2.34)  LDD2265  [1]
 LDCM0023  KB03 AU565 C158(4.63); C324(2.80)  LDD2682  [1]
 LDCM0024  KB05 NCI-H2122 C324(3.81)  LDD3354  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019