Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP17760
Target Name	Coiled-coil domain-containing protein 89 (CCDC89)
Gene Name	CCDC89
Gene ID	220388
Synonyms	BOIP; Coiled-coil domain-containing protein 89; Bc8 orange-interacting protein
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDSVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIGENWEEKNIEDHKNQGR KLRSHMVERLCERKEGSQFGETISQTPNPKPNKKTFTRVKPYECSVCGKDYMCHSSLNRH MRSHTEHRSYEYHKYGEKSYECKECGKRFSFRSSFRIHERTHTGEKPYKCKQCGKAFSWP SSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKECGKTFSHPSSFR NHERTHSGEKPYECKQCGKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHER IHTGEKPYKCKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHTG NGPYKCKECGKAFDCPSSFQIHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPH ECKQCGKAFSCSSSVRIHERTHTGEKPYECKQCGKAFSCSSSFRMHERIHTGEKPYECKQ CGKAFSFSSSFRMHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPYECKQCGKA FSCSSSIRIHERTHTGEKPYECKQCGKAFSCSSSVRMHERTHTGVKPYECKQCDKAFSCS RSFRIHERTHTGEKPYACQQCGKAFKCSRSFRIHERVHSGE
Target Bioclass	Other
Family	CCDC89 family
Subcellular location	Cytoplasm
Uniprot ID	Q8N998
Ensemble ID	ENST00000316398.5
HGNC ID	HGNC:26762

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
DBIA Probe Info			C197(2.46); C202(2.46)	LDD0080	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0022	KB02	HCT 116	C197(2.46); C202(2.46)	LDD0080	[1]
LDCM0023	KB03	HCT 116	C197(1.19); C202(1.19)	LDD0081	[1]
LDCM0024	KB05	HCT 116	C197(2.47); C202(2.47)	LDD0082	[1]

References

1	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.