Details of the Target

General Information of Target

Target ID LDTP17735
Target Name Leucine-rich repeat-containing protein 17 (LRRC17)
Gene Name LRRC17
Gene ID 10234
Synonyms
P37NB; Leucine-rich repeat-containing protein 17; p37NB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGRSLCLTRSSVPGTPFPPPVQQPSTPGPDLLALEEEYKRLNAELQAKTADVVQQAKEI
IRDRQEVRSRPVSTQMKSCDDEDDYSLRGLLPSEGIVHLHSETKPKTKNIDPVNKVQNKL
HSANKGRKTNSSVKLKYSDVQTADDVAIPEDFSDFSLAKTISKIEGQLEEEGLPEYIDDI
FSGVSNDIGTEAQIRFLKAKLHVMQEELDNVVCECNKKEDEIQNLKSQVKNFEEDFMRQQ
RTINMQQSQVEKYKTLFEEANKKYDGLQQQLSSVERELENKRRLQKQAASSQSATEVRLN
RALEEAEKYKLELSKLRQNNKDIANEEHKKIEVLKSENKKLEKQKGELMIGFKKQLKLID
VLKRQKMHIEAAKMLSFTEEEFMKALEWGNS
Target Bioclass
Other
Subcellular location
Secreted, extracellular space
Function Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.
Uniprot ID
Q8N6Y2
Ensemble ID
ENST00000249377.4
HGNC ID
HGNC:16895

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.D308Y .
AN3CA Deletion: p.K424NfsTer12 .
DU145 Deletion: p.L313Ter .
EFO21 SNV: p.P409S .
HCT15 Deletion: p.K424NfsTer12 .
OCIAML5 SNV: p.T173M .
SKN SNV: p.R34Q .
SNU1 Deletion: p.K424NfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C192(1.70)  LDD2157  [1]
DBIA
 Probe Info  		C67(3.95)  LDD3401  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 RD C67(3.22)  LDD2567  [2]
 LDCM0023  KB03 RD C67(5.62)  LDD2984  [2]
 LDCM0024  KB05 RD C67(3.95)  LDD3401  [2]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840