Details of the Target

General Information of Target

Target ID LDTP17733
Target Name Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A)
Gene Name TMCO5A
Gene ID 145942
Synonyms
TMCO5; Transmembrane and coiled-coil domain-containing protein 5A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALQADFDRAAEDVRKLKARPDDGELKELYGLYKQAIVGDINIACPGMLDLKGKAKWEAW
NLKKGLSTEDATSAYISKAKELIEKYGI
Target Bioclass
Other
Family
TMCO5 family
Subcellular location
Membrane
Uniprot ID
Q8N6Q1
Ensemble ID
ENST00000319669.5
HGNC ID
HGNC:28558

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.N115Y .
SW1116 SNV: p.K222T .
TOV21G Deletion: p.K215RfsTer25 .
YSCCC SNV: p.E29K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 60 (TMEM60) . Q9H2L4
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060