Details of the Target

General Information of Target

Target ID LDTP17704
Target Name Major facilitator superfamily domain-containing protein 4A (MFSD4A)
Gene Name MFSD4A
Gene ID 148808
Synonyms
MFSD4; Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN
LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL
KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP
KPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNL
ISPNSMAKDSWEDWRIRLTSS
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Membrane
Uniprot ID
Q8N468
Ensemble ID
ENST00000367147.9
HGNC ID
HGNC:25433

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L483S .
KMCH1 SNV: p.M452I .
LNCaP clone FGC SNV: p.K212N .
SCC25 SNV: p.L391V .
VMRCRCW SNV: p.W224Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0167  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060