Details of the Target

General Information of Target

Target ID LDTP17694
Target Name Chemokine-like protein TAFA-2 (TAFA2)
Gene Name TAFA2
Gene ID 338811
Synonyms
FAM19A2; Chemokine-like protein TAFA-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVSVPGPAAAAAPAAGREPSTPGGGSGGGGAVAAASGAAVPGSVQLALSVLHALLYAAL
FAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLH
FFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDRHKILLHLGFIMASLLFLVV
NLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVCYICKITKMSSANVYLESKG
MSLCQTVVVGSVVILLYSSRACYNLVVVTISQDTLESPFNYGWDNLSDKAHVEDISGEEY
IVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDD
LPRLGSSREGSLPNSQSLGWYGTMTGCGSSSYTVTPHLNGPMTDTAPLLFTCSNLDLNNH
HSLYVTPQN
Target Bioclass
Cytokine and receptor
Family
TAFA family
Subcellular location
Cytoplasm
Function Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions.
Uniprot ID
Q8N3H0
Ensemble ID
ENST00000416284.8
HGNC ID
HGNC:21589

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.K3E .
A3KAW SNV: p.A87S .
HDMYZ SNV: p.Ter132YextTer26 .
MELJUSO SNV: p.G12E .
RH41 SNV: p.V85G .
SKMEL24 SNV: p.L110F .
TE1 SNV: p.R79Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]
W1
 Probe Info  		Y5(0.00); R4(0.00); S2(0.00)  LDD0236  [2]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.