Details of the Target

General Information of Target

Target ID LDTP17673
Target Name Protein canopy homolog 4 (CNPY4)
Gene Name CNPY4
Gene ID 245812
Synonyms
Protein canopy homolog 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLESNYTMPTEFLFVGFTDYLPLRVTLFLVFLLVYTLTMVGNILLIILVNINSSLQIPMY
YFLSNLSFLDISCSTAITPKMLANFLASRKSISPYGCALQMFFFASFADAECLILAAMAY
DRYAAICNPLLYTTLMSRRVCVCFIVLAYFSGSTTSLVHVCLTFRLSFCGSNIVNHFFCD
IPPLLALSCTDTQINQLLLFALCSFIQTSTFVVIFISYFCILITVLSIKSSGGRSKTFST
CASHLIAVTLFYGALLFMYLQPTTSYSLDTDKVVAVFYTVVFPMFNPIIYSFRNKDVKNA
LKKLLERIGYSNEWYLNRLRIVNI
Target Bioclass
Other
Family
Canopy family
Subcellular location
Secreted
Function Plays a role in the regulation of the cell surface expression of TLR4.
Uniprot ID
Q8N129
Ensemble ID
ENST00000262932.5
HGNC ID
HGNC:28631

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0109  NEM HeLa N.A.  LDD0226  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferroptosis suppressor protein 1 (AIFM2) FAD-dependent oxidoreductase family Q9BRQ8

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060