Details of the Target

General Information of Target

Target ID LDTP17664
Target Name Putative protein FAM10A4 (ST13P4)
Gene Name ST13P4
Synonyms
FAM10A4; Putative protein FAM10A4; Suppression of tumorigenicity 13 pseudogene 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGAMKIFVFILAALILLAQIFQARTAIHRALISKRMEGHCEAECLTFEVKIGGCRAELA
PFCCKNRKKH
Target Bioclass
Other
Family
FAM10 family
Subcellular location
Cytoplasm
Uniprot ID
Q8IZP2
HGNC ID
HGNC:18487

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D131(0.92); E119(0.96)  LDD2208  [1]
DBIA
 Probe Info  		C209(1.15)  LDD3310  [2]
BTD
 Probe Info  		C167(0.93)  LDD2120  [3]
HHS-475
 Probe Info  		Y147(0.91)  LDD0264  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
Acrolein
 Probe Info  		C205(0.00); H199(0.00)  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
HHS-465
 Probe Info  		K114(0.00); K14(0.00); K149(0.00); K47(0.00)  LDD2240  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa C205(0.00); H193(0.00); H199(0.00)  LDD0222  [8]
 LDCM0116  HHS-0101 DM93 Y147(0.91)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y147(1.03)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y147(1.03)  LDD0266  [4]
 LDCM0120  HHS-0701 DM93 Y147(0.97)  LDD0268  [4]
 LDCM0107  IAA HeLa C205(0.00); H199(0.00); H193(0.00)  LDD0221  [8]
 LDCM0022  KB02 42-MG-BA C209(1.44)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C209(1.63)  LDD2661  [2]
 LDCM0024  KB05 COLO792 C209(1.15)  LDD3310  [2]
 LDCM0109  NEM HeLa H199(0.00); H193(0.00)  LDD0223  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C167(0.93)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C167(0.21)  LDD2122  [3]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010