Details of the Target

General Information of Target

Target ID LDTP17660
Target Name Sterile alpha motif domain-containing protein 14 (SAMD14)
Gene Name SAMD14
Gene ID 201191
Synonyms
Sterile alpha motif domain-containing protein 14; SAM domain-containing protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFISLWEFFYGHFFRFWMKWLLRQMTGKCELQRIFDTYVGAQRTHRIENSLTYSKNKVLQ
KATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPY
DSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYF
SENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEH
FHQFYCYLVYEFDKFWFEEEPESIMYFNLYREKFHEKIKGLLLDCNVALTLKV
Target Bioclass
Other
Uniprot ID
Q8IZD0
Ensemble ID
ENST00000330175.9
HGNC ID
HGNC:27312

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.D280E .
MDAMB453 SNV: p.R34G .
MDST8 SNV: p.D317N .
MEWO SNV: p.E111A .
SF295 SNV: p.D149N .
SKMEL28 SNV: p.Q336E .
TC71 SNV: p.S220G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		D375(0.00); H374(0.00); R376(0.00)  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.