Details of the Target

General Information of Target

Target ID LDTP17649
Target Name Protein FAM186B (FAM186B)
Gene Name FAM186B
Gene ID 84070
Synonyms
C12orf25; Protein FAM186B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLTSSSHKATDTRTSKKFK
CDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSALLPGSEAGVSVQQGAASLP
LGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQKQNEPGLQTEDVQKPPLQMD
NSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDDDDDDD
AEM
Target Bioclass
Other
Family
FAM186 family
Uniprot ID
Q8IYM0
Ensemble ID
ENST00000257894.2
HGNC ID
HGNC:25296

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.A324D .
JURLMK1 SNV: p.R876Q .
KPL1 SNV: p.W566C .
LS180 SNV: p.S436R .
MCC13 SNV: p.P372L .
MCF7 SNV: p.W566C .
MFE319 SNV: p.G485D .
NCIH1666 SNV: p.T213K .
NCIH716 SNV: p.K868Ter .
NOMO1 SNV: p.R276S .
RL952 SNV: p.L891P .
T24 SNV: p.F616C .
TOV21G SNV: p.L417F .
YSCCC Deletion: p.T13del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K856(9.09)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal membrane protein PEX14 (PEX14) Peroxin-14 family O75381

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.