Details of the Target

General Information of Target

Target ID LDTP17625
Target Name Ankyrin repeat domain-containing protein 18A (ANKRD18A)
Gene Name ANKRD18A
Gene ID 253650
Synonyms
KIAA2015; Ankyrin repeat domain-containing protein 18A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGEAEAQLDPSLQGLVMFEDVTVYFSREEWGLLNVTQKGLYRDVMLENFALVSSLGLAP
SRSPVFTQLEDDEQSWVPSWVDVTPVSRAEARRGFGLDGLCRVEDERAHPEHLKSYRVIQ
HQDTHSEGKPRRHTEHGAAFPPGSSCGQQQEVHVAEKLFKCSDCGKVFLKAFALLDHLIT
HSEERPFRCPTGRSAFKKSAHINPRKIHTGETAHVCNECGKAFSYPSKLRKHQKVHTGIK
PFKCSDCGKTFNRKDALVLHQRIHTGERPYECSKCGKTFSVLSTLIRHRKVHIGERPYEC
TECGKFFKYNNSFILHQRVHTGERPFECKQCGKGYVTRSGLYQHWKVHTGERPYECSLCG
KTFTTRSYRNRHQQFHTEERSYECTECGKAFKHSSTLLQHKKVHTPERRQEDRAHGKVVS
C
Target Bioclass
Other
Uniprot ID
Q8IVF6
Ensemble ID
ENST00000399703.6
HGNC ID
HGNC:23643

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.E408G .
AN3CA SNV: p.C648Y .
COLO829 SNV: p.E654K .
DU145 SNV: p.E416D .
FUOV1 SNV: p.E298K .
HT115 SNV: p.F5C .
IM95 Deletion: p.R282EfsTer11 .
KYSE410 SNV: p.M19V .
MEWO SNV: p.R970G .
ONS76 SNV: p.L774V .
OZ SNV: p.A240V .
P31FUJ Insertion: p.R282KfsTer26 .
SUPT1 SNV: p.L394R .
TOV21G SNV: p.L86I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		N.A.  LDD0405  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.