Details of the Target

General Information of Target

Target ID LDTP17605
Target Name Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2)
Gene Name ECHDC2
Gene ID 55268
Synonyms
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGTRHSVGMAVLGQLARRL
GVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSVARAAELFGLTAEEVYLVH
DELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLRVGIGRPAHPEAVQAHVLGCF
SPAEQELLPLLLDRATDLILDHIRERSQGPSLGP
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Mitochondrion
Uniprot ID
Q86YB7
Ensemble ID
ENST00000358358.9
HGNC ID
HGNC:23408

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.A224G .
NB4 SNV: p.I237T .
SKMEL2 Substitution: p.G170R .
SNU1 SNV: p.D218G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C180(5.01)  LDD3369  [1]
IPM
 Probe Info  		C180(6.23)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C180(6.23)  LDD1702  [2]
 LDCM0022  KB02 AU565 C91(1.77)  LDD2265  [1]
 LDCM0023  KB03 AU565 C91(2.88)  LDD2682  [1]
 LDCM0024  KB05 OAW-42 C180(5.01)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761