Details of the Target

General Information of Target

Target ID LDTP17592
Target Name Regulator of DNA class I crossover intermediates 1 (REDIC1)
Gene Name REDIC1
Gene ID 283461
Synonyms
C12orf40; Regulator of DNA class I crossover intermediates 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVTHRKSDASDMNSDTSPSCRLRAFSRGGSLESRSSSSRSRSFTLDDESLKYLTHEEKD
VLLFFEETIDSLDEDFEEPVLCDGGVCCLCSPSLEESTSSPSEPEDVIDLVQPAPGAGEA
EGLPEGTQAAGPAPAGKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPPRRELRAPSP
PVEHPRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAARGPRSGDPGP
GPSHPAQPKAPRFPSNIIVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAG
DAGEGAPGGGSSPERVARGRGLPGPAESLRAGGQAPRGPALANGFPSAHEALKSAPSSFA
PAGKSLCFRPGPALPSTRARQSFPGPRQPNGAQDWRRADSLPRPQGITVQFAGRGSSEEA
RREALRKLGLLRESS
Target Bioclass
Other
Function
Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation. Required for normal germline development and fertility. Required for meiotic progression, complete chromosomal synapsis and crossover formation. Binds double-stranded DNA. However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure. Probably not required for formation of DNA double-strand breaks (DSBs). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs.
Uniprot ID
Q86WS4
Ensemble ID
ENST00000324616.9
HGNC ID
HGNC:26846

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P67S .
A3KAW SNV: p.G5R .
IGROV1 Deletion: p.N561IfsTer43 .
LS180 SNV: p.E312D .
MFE319 SNV: p.Ter653QextTer7 .
OVK18 Deletion: p.K186SfsTer19 .
SBC5 SNV: p.N114K .
SKMEL3 SNV: p.S7F .
SNGM SNV: p.R379K .
SUPT1 Insertion: p.I617NfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Dynein light chain 2, cytoplasmic (DYNLL2) Dynein light chain family Q96FJ2
LIM domain transcription factor LMO4 (LMO4) . P61968

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.