Details of the Target

General Information of Target

Target ID LDTP17584
Target Name Leucine-rich repeat transmembrane neuronal protein 4 (LRRTM4)
Gene Name LRRTM4
Gene ID 80059
Synonyms
Leucine-rich repeat transmembrane neuronal protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAHMSGLEIMDEDQLIKDVLDKFLNCHEQTYDEEFLNTFTHLSQEDHVSKRGVFGTDSS
ENIFTSAKVTHKNEADDYHLRNKTIFLRTSSQCLEEQVDNFLDLEDLDMDEEIKPQMSED
LLLLPGEVEQDVSTSIPSCIPFVAQPPTCEVKPKPSVKRMDKQTEEILGDEVQLFSLDEE
FDYDNVMLTSKFSPAEIENIKELCKQQKRKDTSPDLEKSCD
Target Bioclass
Transporter and channel
Family
LRRTM family
Subcellular location
Cell membrane
Function May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation.
Uniprot ID
Q86VH4
Ensemble ID
ENST00000409088.3
HGNC ID
HGNC:19411

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 SNV: p.V374A .
KMS27 SNV: p.L159H .
MDAMB468 SNV: p.Q146K .
MEWO SNV: p.E314K; p.E515K .
MM1S SNV: p.S233Ter .
NCIH1793 Substitution: p.G203L .
NCIH2170 SNV: p.C275S .
NCIH2172 Substitution: p.L124P .
NCIH23 SNV: p.M496I .
OE33 SNV: p.L19H .
PF382 SNV: p.Y528C .
SNU1 Deletion: p.K469RfsTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060