Details of the Target

General Information of Target

Target ID LDTP17572
Target Name Zinc finger protein 605 (ZNF605)
Gene Name ZNF605
Gene ID 100289635
Synonyms
Zinc finger protein 605
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNTTVPNAPQANSDSMVGYVLGPFFLITLVGVVVAVVMYVQKKKRVDRLRHHLLPMYSY
DPAEELHEAEQELLSDMGDPKVVHGWQSGYQHKRMPLLDVKT
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q86T29
Ensemble ID
ENST00000360187.9
HGNC ID
HGNC:28068

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.Q272E .
HEC1 SNV: p.T16M .
HEC1B SNV: p.S347N .
IGROV1 SNV: p.T136I .
JURKAT SNV: p.Q208H .
KNS42 SNV: p.K334R .
NCIH2172 SNV: p.C283F .
NCIH82 SNV: p.E19Ter .
TE4 SNV: p.H137N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		C507(0.00); C510(0.00); E509(0.00); R511(0.00)  LDD0246  [1]
N1
 Probe Info  		N.A.  LDD0245  [1]
DBIA
 Probe Info  		C104(0.24)  LDD2236  [2]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730