Details of the Target

General Information of Target

Target ID LDTP17567
Target Name Zinc finger protein 467 (ZNF467)
Gene Name ZNF467
Gene ID 168544
Synonyms
Zinc finger protein 467
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSAL
KECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex.
Uniprot ID
Q7Z7K2
Ensemble ID
ENST00000302017.4
HGNC ID
HGNC:23154

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C375(1.74)  LDD3343  [1]
NAIA_5
 Probe Info  		C49(0.78)  LDD2227  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C49(0.78)  LDD2227  [2]
 LDCM0022  KB02 22RV1 C75(1.89)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C75(1.56)  LDD2660  [1]
 LDCM0024  KB05 NCI-H1299 C375(1.74)  LDD3343  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264