Details of the Target

General Information of Target

Target ID LDTP17559
Target Name Ras-related protein Rab-44 (RAB44)
Gene Name RAB44
Gene ID 401258
Synonyms
Ras-related protein Rab-44
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMA
LCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPA
EQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLE
VLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQ
LFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAV
ELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHW
KALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDK
FLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARL
RGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEP
NRHFYREMQSFSEDI
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Uniprot ID
Q7Z6P3
Ensemble ID
ENST00000612677.6
HGNC ID
HGNC:21068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C950(2.16)  LDD3333  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 K052 C881(1.39)  LDD2427  [1]
 LDCM0023  KB03 K052 C881(1.94)  LDD2844  [1]
 LDCM0024  KB05 MOLM-13 C950(2.16)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840