Details of the Target

General Information of Target

Target ID LDTP17555
Target Name Transmembrane channel-like protein 3 (TMC3)
Gene Name TMC3
Gene ID 342125
Synonyms
Transmembrane channel-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIITTWIVYILARKGVGLPFLPITSSDIDVVESEAVSVLHHWLKKTEEEASRGIKEKLSI
NHPSQGVREKMSTDSPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWS
HTRIFQVPSEMTEDIMRDRIEQVRRSISRLTDVSAQDFSMRPSSSDC
Target Bioclass
Transporter and channel
Family
TMC family
Subcellular location
Membrane
Function Probable ion channel.
Uniprot ID
Q7Z5M5
Ensemble ID
ENST00000359440.6
HGNC ID
HGNC:22995

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.W123Ter .
COLO792 SNV: p.E1040K .
EFO21 SNV: p.E785K .
HEC1 SNV: p.Q304H .
HEC1B SNV: p.Q304H .
HT115 SNV: p.A485T .
HUH7 SNV: p.A290P .
KYSE180 SNV: p.T519I .
MEWO SNV: p.A290P .
NCIH1793 SNV: p.A331D; p.C580S .
RKO Deletion: p.H883TfsTer19
SNV: p.Q172R;p.N768S		 .
RL952 SNV: p.N53D .
SW480 Deletion: p.F577del .
SW620 Deletion: p.F577del .
TGBC52TKB SNV: p.K487M .
YSCCC SNV: p.M421I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N.A.  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.